Sauar J, Holme R, Blomhoff J P
Clin Chim Acta. 1978 Aug 1;87(3):327-40. doi: 10.1016/0009-8981(78)90175-4.
Hepatic lipase activity and lipoprotein lipase activity were studied in postheparin plasma from 14 patients with various liver disorders. Plasma lecithin: cholesterol acyltransferase (LCAT) activity and lipoprotein composition and structure were also estimated. Five patients had lower hepatic lipase activity than the lowest control value, and in three of these no hepatic lipase activity was detected. Lipoprotein lipase was low in 5 patients, but in only one of them was hepatic lipase activity also low. Hepatic lipase was not significantly correlated to the concentration of plasma triglycerides, either in controls or in patients, whereas lipoprotein lipase was negatively correlated with plasma triglycerides both in controls and patients. Lipoprotein lipase and LCAT activity, but not hepatic lipase, was negatively correlated to the triglyceride content of the low density lipoproteins (density 1.019-1.063 g/ml) from the patients. No specific lipid or lipoprotein pattern was found in plasma from the patients with a low or without any hepatic lipase activity. The results suggest an important role of lipoprotein lipase and LCAT, for the increased content of triglycerides in the low density lipoproteins in patients with liver disease. The role of hepatic lipase remains unclear.
对14例患有各种肝脏疾病患者的肝素后血浆中的肝脂酶活性和脂蛋白脂肪酶活性进行了研究。还评估了血浆卵磷脂：胆固醇酰基转移酶（LCAT）活性以及脂蛋白的组成和结构。5例患者的肝脂酶活性低于最低对照值，其中3例未检测到肝脂酶活性。5例患者的脂蛋白脂肪酶水平较低，但其中只有1例的肝脂酶活性也较低。无论是在对照组还是患者中，肝脂酶与血浆甘油三酯浓度均无显著相关性，而在对照组和患者中，脂蛋白脂肪酶均与血浆甘油三酯呈负相关。患者的脂蛋白脂肪酶和LCAT活性（而非肝脂酶）与低密度脂蛋白（密度1.019 - 1.063 g/ml）的甘油三酯含量呈负相关。在肝脂酶活性低或无肝脂酶活性的患者血浆中未发现特定的脂质或脂蛋白模式。结果表明，脂蛋白脂肪酶和LCAT在肝病患者低密度脂蛋白甘油三酯含量增加方面起重要作用。肝脂酶的作用仍不清楚。
