[对屋尘螨粉尘螨致敏患者中变应原特异性IgE和IgG抗体的测定]

[The determination of allergen-specific IgE and IgG antibodies in patients sensitized to the house dust mite Dermatophagoides pteronyssinus].

作者信息

Golysheva M A, Glikman M V, Berzhets V M, Prilepina T A, Pakhomova L A

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1990 Dec(12):86-8.

Abstract

45 patients, hypersensitive to house-dust mites, were examined by the method of skin tests to D. pteronyssinus allergen. Besides, in their blood sera the levels of allergen-specific IgE antibodies were determined in the radioallergosorbent test and allergen-specific IgG antibodies, in the enzyme immunoassay. These tests revealed that in 91% of the patients the results of skin tests were positive, in 68% an elevated level of specific IgE antibodies and in 93% of the patients an elevated level of specific IgG antibodies were detected. All patients showed the positive result in one of the above-mentioned tests. The largest group of the patients (55%) included persons showing the positive result of the skin test and having elevated levels of allergen-specific IgG and IgE antibodies. Thus, in cases of hypersensitivity to house-dust mites the levels of allergen-specific IgG and IgE antibodies in the patients' blood sera should be determined.

摘要

采用针对粉尘螨变应原的皮肤试验方法对45名对屋尘螨过敏的患者进行了检查。此外，通过放射变应原吸附试验测定了他们血清中变应原特异性IgE抗体的水平，并通过酶免疫测定法测定了变应原特异性IgG抗体的水平。这些检测结果显示，91%的患者皮肤试验结果呈阳性，68%的患者特异性IgE抗体水平升高，93%的患者特异性IgG抗体水平升高。所有患者在上述检测中均呈现阳性结果。最大的一组患者（55%）包括皮肤试验结果呈阳性且变应原特异性IgG和IgE抗体水平升高的人。因此，在对屋尘螨过敏的情况下，应测定患者血清中变应原特异性IgG和IgE抗体的水平。