Virchow C, Roth A, Möller E
Clin Allergy. 1976 Mar;6(2):147-54. doi: 10.1111/j.1365-2222.1976.tb01892.x.
Fifty-three patients were investigated by intradermal tests and Phadebas RAST and, in most cases, the serum IgE level was determined. They were tested for sensitivity to house dust, Dermatophagoides pteronyssinus, cat, dog, horse and mould allergens. All cases with IgE antibodies to house dust were found to have specific IgE to other tested allergens as well. Eighty-nine per cent of the patients being RAST positive for house dust were also positive for D. pteronyssinus and in the majority of those cases IgE antibodies to other allergens were detected. The results reaffirm previous findings that the mite is not the only allergen in house dust and that extract of house dust is a mixture of several allergenic substances, which make it less suitable for differential testing. It is concluded that serum IgE determination is of value as a screening procedure in the diagnosis and that the use of a number of specific allergens in RAST is valuable in pinpointing the offending allergen in house dust hypersensitivity.
对53名患者进行了皮内试验和Phadebas RAST检测，多数情况下还测定了血清IgE水平。检测了他们对屋尘、粉尘螨、猫、狗、马和霉菌过敏原的敏感性。所有对屋尘有IgE抗体的病例也被发现对其他检测的过敏原具有特异性IgE。屋尘RAST阳性的患者中，89%对粉尘螨也呈阳性，并且在大多数此类病例中检测到了针对其他过敏原的IgE抗体。结果再次证实了先前的发现，即螨虫不是屋尘中唯一的过敏原，屋尘提取物是几种致敏物质的混合物，这使得它不太适合用于鉴别检测。结论是，血清IgE测定作为诊断中的筛查程序具有价值，并且在RAST中使用多种特异性过敏原对于确定屋尘过敏反应中的致病过敏原很有价值。
