三甘氨酰加压素对正常及肝硬化大鼠门静脉压力和门静脉胆汁酸浓度的影响。
Effects of triglycylvasopressin on portal pressure and portal bile acid concentration in normal and cirrhotic rats.
作者信息
Testa R, Ghia M, Mereto E, Dagnino F, Grasso A, Lapertosa G, Celle G
机构信息
Department of Gastroenterology, University of Genova, Italy.
出版信息
Arch Int Pharmacodyn Ther. 1990 Nov-Dec;308:115-22.
The effects of triglycylvasopressin on portal vein pressure and portal bile acid concentration after oral loading with chenodeoxycholic acid were evaluated in normal and cirrhotic rats. Triglycylvasopressin significantly reduced the portal vein pressure and portal bile acid concentration in both populations (normal: portal vein pressure 21.2%, p less than 0.05; portal bile acid concentration 43.2%, p less than 0.005; cirrhotic: portal vein pressure 19.8%, p less than 0.025; portal bile acid concentration 20.3%, p less than 0.05). Both in normal and cirrhotic rats, portal vein pressure and portal bile acid concentration resulted correlated. These results support that the combined determination of portal vein pressure and portal bile acid concentration could represent an interesting approach to the study of drugs which are potentially active on portal circulation and could indirectly provide information as to portal flow.
在正常大鼠和肝硬化大鼠中评估了三甘氨酰加压素对口服鹅去氧胆酸后门静脉压力和门静脉胆汁酸浓度的影响。三甘氨酰加压素显著降低了两组大鼠的门静脉压力和门静脉胆汁酸浓度（正常组：门静脉压力降低21.2%，p<0.05；门静脉胆汁酸浓度降低43.2%，p<0.005；肝硬化组：门静脉压力降低19.8%，p<0.025；门静脉胆汁酸浓度降低20.3%，p<0.05）。在正常大鼠和肝硬化大鼠中，门静脉压力和门静脉胆汁酸浓度均呈相关。这些结果支持，联合测定门静脉压力和门静脉胆汁酸浓度可能是研究对门静脉循环有潜在活性的药物的一种有趣方法，并且可以间接提供有关门静脉血流的信息。
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