Neumann B G, Troncone L R, Braz S, Tufik S
Department of Psychobiology, Escola Paulista de Medicina, São Paulo, Brasil.
Arch Int Pharmacodyn Ther. 1990 Nov-Dec;308:32-8.
Animals deprived of REM sleep by the water tank technique show an important decrease in frequency of yawning, induced by dopaminergic (apomorphine in low doses) and cholinergic (physostigmine and pilocarpine) agonists, if they are tested immediately after the 96 hr of deprivation. In order to understand the mechanisms underlying the effects of REM sleep deprivation on dopaminergic and cholinergic systems, we decided to test the animals after a recovery period of 24 hr. It was observed that apomorphine-induced yawning was still significantly reduced, whereas pilocarpine-induced yawning had returned to normal. The findings suggest that REM sleep deprivation alters dopaminergic and cholinergic systems in different ways: it seems that the interference on the dopaminergic system is prior and stronger than on the cholinergic system, thus its recovery demands more time.
通过水箱技术剥夺快速眼动睡眠的动物，如果在剥夺96小时后立即进行测试，由多巴胺能（低剂量阿扑吗啡）和胆碱能（毒扁豆碱和毛果芸香碱）激动剂诱导的打哈欠频率会显著降低。为了了解快速眼动睡眠剥夺对多巴胺能和胆碱能系统影响的潜在机制，我们决定在24小时的恢复期后对动物进行测试。结果发现，阿扑吗啡诱导的打哈欠仍然显著减少，而毛果芸香碱诱导的打哈欠已恢复正常。这些发现表明，快速眼动睡眠剥夺以不同方式改变多巴胺能和胆碱能系统：似乎对多巴胺能系统的干扰比胆碱能系统更早且更强，因此其恢复需要更多时间。
