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Does REM sleep deprivation induce subsensitivity of presynaptic dopamine or postsynaptic acetylcholine receptors in the rat brain?

作者信息

Tufik S, Troncone L R, Braz S, Silva-Filho A R, Neumann B G

机构信息

Department of Psychobiology, Escola Paulista de Medicina, São Paulo, Brazil.

出版信息

Eur J Pharmacol. 1987 Aug 11;140(2):215-9. doi: 10.1016/0014-2999(87)90808-9.

DOI:10.1016/0014-2999(87)90808-9
PMID:3666018
Abstract

Yawning behavior was used to evaluate the sensitivity of presynaptic dopamine receptors and postsynaptic acetylcholine receptors of normal and REM sleep-deprived (REMSD) rats. The results show a lowering of the dose-response curve obtained with apomorphine and pilocarpine, as well as a shift to the right in the curve obtained with physostigmine. These results suggest that REMSD induces subsensitization of presynaptic dopamine receptors and/or postsynaptic acetylcholine receptors with different characteristics related to the mechanism of action of the cholinomimetic agent employed.

摘要

相似文献

1
Does REM sleep deprivation induce subsensitivity of presynaptic dopamine or postsynaptic acetylcholine receptors in the rat brain?
Eur J Pharmacol. 1987 Aug 11;140(2):215-9. doi: 10.1016/0014-2999(87)90808-9.
2
Atropine increases pilocarpine-induced yawning behavior in paradoxical sleep deprived rats.阿托品可增加处于异相睡眠剥夺状态大鼠中毛果芸香碱诱导的打哈欠行为。
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Modifications on dopaminergic and cholinergic systems induced by the water tank technique: analysis through yawning behavior.水箱技术对多巴胺能和胆碱能系统的影响：通过打哈欠行为进行分析。
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Increased responsiveness to apomorphine after REM sleep deprivation: supersensitivity of dopamine receptors or increase in dopamine turnover?快速眼动睡眠剥夺后对阿扑吗啡反应性增加：多巴胺受体超敏还是多巴胺代谢增加？
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REM sleep deprivation induces subsensitivity of dopamine receptors mediating sedation in rats.快速眼动睡眠剥夺会导致介导大鼠镇静作用的多巴胺受体敏感性降低。
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Yawning induced by apomorphine, physostigmine or pilocarpine is potentiated by dihydropyridine calcium channel blockers.
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Two inbred rat sublines that differ in spontaneous yawning behavior also differ in their responses to cholinergic and dopaminergic drugs.
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