Nishida M, Yoshimura Y, Kawada J, Ookubo A, Kagawa T, Ikawa A, Hashimura Y, Suzuki T
Faculty of Pharmaceutical Sciences, University of Tokushima, Japan.
Biochem Int. 1990 Dec;22(5):913-20.
A new microcrystalline compound of aluminum oxide hydroxide (tentatively named PT-A) was synthesized in the hope of providing a better phosphate adsorbent for future clinical use than the currently marketed aluminum hydroxide gels (ALG). An X-ray diffraction study demonstrated a boehmite structure in PT-A but an amorphous structure in ALG. PT-A was more stable in pH change than ALG; in elution tests in artificial gastric and intestinal solutions, aluminum ion eluted from PT-A was maximally 10% of the amount from ALG at pH 1.2; and was undetectable at pH 6.8, at which point ALG still showed some aluminum elution. Phosphate-adsorbing efficacy of PT-A and ALG in vitro was about the same at pH 1.2; however, it was four times greater in PT-A than in ALG at pH 6.8, indicating that PT-A will be effective in the intestine. PT-A also adsorbed pepsin but the amount was at most the same or much less than that adsorbed by ALG, which depended on pH in solution.
合成了一种新型氢氧化铝微晶化合物（暂定名为PT-A），希望能为未来临床应用提供一种比目前市售氢氧化铝凝胶（ALG）更好的磷酸盐吸附剂。X射线衍射研究表明，PT-A具有勃姆石结构，而ALG具有无定形结构。PT-A在pH变化方面比ALG更稳定；在人工胃液和肠液中的洗脱试验中，在pH 1.2时，从PT-A洗脱的铝离子最多为从ALG洗脱量的10%；在pH 6.8时未检测到铝离子，而此时ALG仍有一些铝离子洗脱。在pH 1.2时，PT-A和ALG的体外磷酸盐吸附效果大致相同；然而，在pH 6.8时，PT-A的吸附效果是ALG的四倍，这表明PT-A在肠道中会有效。PT-A也能吸附胃蛋白酶，但吸附量最多与ALG相同或比ALG少得多，这取决于溶液的pH值。
