Legros J J
Unité de Neuro-endocrinologie du service d'Endocrinologie, C.H.U. de l'Université de Liège au Sart-Tilman.
Bull Mem Acad R Med Belg. 1990;145(11):429-35; discussion 435-9.
Neurophysins are neuropeptides (MW +/- 10,000) synthetized together with active nonapeptides vasopressin (AVP) and oxytocin (OT). The original description of the radioimmunoassay for neurophysins in 1969 allowed us to demonstrate the concomitant, equimolecular, release of them together with AVP and OT, thus bringing strong arguments in favour of neurohypophyseal exocytosis. Beside the use of those RIAs as direct indexes of neurohypophyseal release in various physiological and pathological conditions, we have been interested these last two years, to the putative use of neurophysins RIA as direct neuroendocrine markers in various neuropsychiatric diseases (depression, mania, schizophrenia) and paraneoplastic syndromes (SIADH).
神经垂体激素运载蛋白是与活性九肽血管加压素（AVP）和催产素（OT）一起合成的神经肽（分子量约为10,000）。1969年对神经垂体激素运载蛋白放射免疫测定法的最初描述，使我们能够证明它们与AVP和OT同时、等分子地释放，从而为神经垂体胞吐作用提供了有力证据。除了将这些放射免疫测定法用作各种生理和病理条件下神经垂体释放的直接指标外，在过去两年中，我们一直关注神经垂体激素运载蛋白放射免疫测定法在各种神经精神疾病（抑郁症、躁狂症、精神分裂症）和副肿瘤综合征（抗利尿激素分泌不当综合征）中作为直接神经内分泌标志物的潜在用途。
