Naito Y, Shindo N, Sato R, Murakami D
Department of Veterinary Internal Medicine, Iwate University, Morioka, Japan.
J Dairy Sci. 1990 Dec;73(12):3481-4. doi: 10.3168/jds.S0022-0302(90)79047-9.
The purpose of the present study was to determine changes of plasma osteocalcin levels in periparturient cows and to examine the correlation of plasma osteocalcin level with that of 1,25-dihydroxyvitamin D, Ca, and inorganic P. Five Holstein-Friesian cows, aged 3 to 5 yr, were used from 5 d before to 15 d after calving. Concentration (mean +/- SE) of plasma osteocalcin decreased rapidly from d 1 prepartum, reached a low of 8.0 +/- 3.0 ng/ml at d 1 postpartum, and then recovered gradually to 17.8 +/- 3.8 ng/ml at 15 d after calving. In contrast, the concentration of plasma 1,25-dihydroxyvitamin D increased from calving to 3 d postpartum. Plasma concentrations of osteocalcin did not correlate significantly with those of 1,25-dihydroxyvitamin D, but it was significantly proportional to that of Ca and inorganic P. It is suggested that osteoblast function is depressed by a number of factors around the time of parturition.
本研究的目的是确定围产期奶牛血浆骨钙素水平的变化，并检测血浆骨钙素水平与1,25-二羟维生素D、钙和无机磷水平的相关性。选用5头3至5岁的荷斯坦-弗里生奶牛，从产前5天至产后15天进行观察。血浆骨钙素浓度（平均值±标准误）在产前1天迅速下降，产后1天降至最低点8.0±3.0 ng/ml，然后在产后15天逐渐恢复至17.8±3.8 ng/ml。相比之下，血浆1,25-二羟维生素D浓度从分娩至产后3天升高。血浆骨钙素浓度与1,25-二羟维生素D浓度无显著相关性，但与钙和无机磷浓度显著相关。提示分娩前后多种因素抑制成骨细胞功能。
