Dobbins D E
Department of Physiology Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799.
Microcirc Endothelium Lymphatics. 1990 Dec;6(6):465-81.
Calcitonin gene-related peptide (CGRP) is a 37 amino acid peptide which is found in high concentrations in the perivascular nerves innervating the resistance vessels of the peripheral circulation. In the current study we have infused CGRP at three infusion rates (.01, .1 and 1.0 micrograms/min into the brachial artery for thirty minutes at each infusion rate) in the isolated, innervated canine forelimb perfused at natural flow. We measured large artery and vein pressures, small artery and vein pressures and blood flows in both the skin and skeletal muscle circulations for the calculation of total and segmental (large artery, small vessel and large vein) vascular resistances. Infusion of the lowest dosage of CGRP produced slight vasodilation in some animals but did not significantly alter the mean resistances of all the animals as a group. The middle dosage resulted in a 55% decrease in total forelimb resistance and a small but significant decrease in systemic arterial pressure. The highest dosage of CGRP resulted in a 65% decrease in total forelimb resistance and a 34% decrease in systemic arterial pressure. The decreases in forelimb resistances were equally distributed between skin and muscle and were manifested in both large artery and small vessel resistances. The potent vasodilatory effects of CGRP and its concentration in perivascular nerves innervating the resistance vessels of the peripheral circulation suggests a potential role for CGRP in control of circulatory function under normal and/or pathophysiological conditions.
降钙素基因相关肽（CGRP）是一种由37个氨基酸组成的肽，在支配外周循环阻力血管的血管周围神经中浓度很高。在本研究中，我们以三种输注速率（0.01、0.1和1.0微克/分钟，每种输注速率持续30分钟）将CGRP注入自然血流灌注的离体、有神经支配的犬前肢肱动脉。我们测量了大动脉和静脉压力、小动脉和静脉压力以及皮肤和骨骼肌循环中的血流，以计算总血管阻力和各节段（大动脉、小血管和大静脉）血管阻力。输注最低剂量的CGRP在一些动物中产生了轻微的血管舒张，但作为一个整体，并未显著改变所有动物的平均阻力。中等剂量导致前肢总阻力降低55%，全身动脉压有小幅但显著的降低。最高剂量的CGRP导致前肢总阻力降低65%，全身动脉压降低34%。前肢阻力的降低在皮肤和肌肉之间平均分布，并且在大动脉和小血管阻力中均有体现。CGRP强大的血管舒张作用及其在支配外周循环阻力血管的血管周围神经中的浓度表明，CGRP在正常和/或病理生理条件下控制循环功能方面可能发挥作用。
