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Cytogenetics and molecular analysis in chronic myelogenous leukemia patients treated by interferon and chemotherapy.

作者信息

Guilhot F, Ahmad M, Mahon F X, Dreyfus B, Brizard A, Huret J L, Kitzis A, Tanzer J

机构信息

Département d'Hématologie et Oncologie Médicale, Hôpital Jean-Bernard, Poitiers, France.

出版信息

Nouv Rev Fr Hematol (1978). 1990;32(5):287-8.

PMID:2099398
Abstract

A new combination regimen including chemotherapy and interferon was started in 1986 for the treatment of 24 chronic myelogenous leukaemia patients in chronic phase. Complete cytogenetic remission were noted in 10 patients and 6 of them are in sustained remission. The overall survival was 70% at 40 months. However, a minimal residual disease was detected in the 3 patients tested with the polymerase chain reaction. In addition no correlation was detected between the site of the breakpoint and response to therapy.

摘要

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