Markus R
Infektionsklinik, Städtischen Krankenhauses Berlin-Prenzlauer Berg.
Z Gesamte Inn Med. 1990 Oct 15;45(20):623-5.
A total of 120 patients with acute viral hepatitis B was investigated for the presence of circulating immune complexes, HBsAg-specific immune complexes, and the behavior of some other immune parameters (immunoglobulins, rosette inhibitory factor RIF, histamine induced inhibition of spontaneous rosette forming lymphocytes). Pathologically elevated levels of circulating immune complexes were seen in 89 per cent of patients, often related to extrahepatic signs in the prodromal phase. In 95.7 per cent of them, HBsAg-containing complexes were found. There were no differences in the behavior of immune complexes between patients with recovery and patients developing chronic hepatitis B. On the contrary, the levels of RIF and differences in the inhibitory effect of histamine on rosette forming test of patient's lymphocytes did allow to distinguish patients with recovery from patients with development of chronic hepatitis B early in the course.
对120例急性乙型病毒性肝炎患者进行了循环免疫复合物、HBsAg特异性免疫复合物以及其他一些免疫参数（免疫球蛋白、玫瑰花结抑制因子RIF、组胺诱导的自发性玫瑰花结形成淋巴细胞抑制）情况的调查。89%的患者循环免疫复合物水平在病理上有所升高，这通常与前驱期的肝外体征有关。其中95.7%的患者发现了含HBsAg的复合物。康复患者与发展为慢性乙型肝炎的患者之间免疫复合物的情况没有差异。相反，RIF水平以及组胺对患者淋巴细胞玫瑰花结形成试验抑制作用的差异确实能够在病程早期将康复患者与发展为慢性乙型肝炎的患者区分开来。
