[抗肿瘤药物研究：N'，N''-二螺三哌嗪鎓的合成]
[Studies on antitumor drugs: the synthesis of N',N"-dispirotripiperaziniums].
作者信息
Chen H C, Liu Z Z, Li R T
机构信息
Department of Chemistry, Zhengzhou University.
出版信息
Yao Xue Xue Bao. 1990;25(10):785-9.
PMID:2099595
Abstract
In order to search for new antitumor drugs, sixteen N',N"-dispirotripiperazine derivatives were synthesized from N',N"-dispirotripiperazinium dichloride dihydrochloride by substitution, acylation and Mannich reaction. Six compounds were selected for preliminary pharmacological test. The result showed that five compounds possess inhibitory action against carcinoma S37 in rats. The inhibitory activity of compounds VI and X was 55.0% and 41.9% respectively.
摘要
为了寻找新的抗肿瘤药物，以二盐酸二氢氯化N',N"-二螺三哌嗪为原料，通过取代、酰化和曼尼希反应合成了16种N',N"-二螺三哌嗪衍生物。选取6种化合物进行初步药理试验。结果表明，有5种化合物对大鼠S37癌具有抑制作用。化合物VI和X的抑制活性分别为55.0%和41.9%。
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