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[低肾素性动脉高血压：钙拮抗剂硝苯地平和血管紧张素转换酶抑制剂依那普利的降压疗效比较]

[Arterial hypertension caused by low renin: comparison of the calcium antagonist nifedipine and the ACE-inhibitor enalapril as to antihypertensive efficacy].

作者信息

Andronico G, Carone M B, Mulè G, Mangano M T, Cerasola G

机构信息

Cattedra di Fisiopatologia Medica, Università di Palermo.

出版信息

Boll Soc Ital Biol Sper. 1990 Dec;66(12):1161-4.

PMID:2100527
Abstract

The aim of this study was to compare the clinical effects of calcium-entry blocker Nifedipine and ACE-inhibitor Enalapril in hypertensive patients with glucose intolerance that have lower plasma renin activity. A blood sample for basal PRA was obtained from 21 subjects; then, 11 patients received Nifedipine (20 mg. b.i.d.) and 10 Enalapril (20 mg. q.d.). The extent of blood pressure fall after 12 weeks of treatment was inversely related to basal PRA levels in Nifedipine treated group only; however, the hypotensive effect of both drugs was comparable.

摘要

本研究的目的是比较钙通道阻滞剂硝苯地平与血管紧张素转换酶抑制剂依那普利对血浆肾素活性较低的糖耐量异常高血压患者的临床疗效。从21名受试者中采集基础血浆肾素活性（PRA）的血样；然后，11名患者接受硝苯地平（20毫克，每日两次），10名患者接受依那普利（20毫克，每日一次）。仅在硝苯地平治疗组中，治疗12周后血压下降程度与基础PRA水平呈负相关；然而，两种药物的降压效果相当。

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Boll Soc Ital Biol Sper. 1990 Dec;66(12):1161-4.
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