Huhtaniemi I, Martikainen H
Mol Cell Endocrinol. 1978 Jul-Aug;11(2):199-204. doi: 10.1016/0303-7207(78)90007-2.
Adults male rats were implanted subcutaneously for 1, 2 or 4 days with Alzet osmotic minipumps, infusing synthetic gonadotropin-releasing hormone (GnRH) at a rate of 0.1 microgram/h. Plasma LH increased significantly, reaching a maximum after 2 days treatment. Plasma and testicular testosterone levels increased to a maximum in 1 day, and decreased gradually thereafter, reaching the control level by day 4. Testicular specific [125I]hCG binding decreased gradually during the treatment, being 57% of the controls by day 4. It is concluded that changes of physiologic magnitude in circulatory LH are able to induce a significant loss of testicular LH/hCG binding capacity. Furthermore, after a short stimulatory phase there is a lack of response in testicular steroidogenesis to the elevated LH levels.
成年雄性大鼠皮下植入Alzet渗透微型泵1、2或4天，以0.1微克/小时的速率输注合成促性腺激素释放激素（GnRH）。血浆促黄体生成素（LH）显著增加，在治疗2天后达到最大值。血浆和睾丸睾酮水平在1天内升至最高，此后逐渐下降，到第4天达到对照水平。治疗期间睾丸特异性[125I]人绒毛膜促性腺激素（hCG）结合能力逐渐下降，到第4天为对照的57%。得出结论：循环中LH的生理性变化能够导致睾丸LH/hCG结合能力显著丧失。此外，在短暂的刺激期后，睾丸类固醇生成对升高的LH水平缺乏反应。
