[氯丙嗪对脂质酶促氧化的影响]
[Effect of aminazin on the enzymatic oxidation of lipids].
作者信息
Eluashvili I A, Pashinova T P, Bogdanova E D, Kagan V E, Prilipko L L
出版信息
Biull Eksp Biol Med. 1977 Sep;84(9):323-6.
PMID:21009
Abstract
An inhibitory effect of chlorpromazine on the enzymatic NADPH-dependent lipid peroxidation in rat liver microsomal fraction was found. This inhibition was caused by the 1) antioxidative effect of hydroxy-derivatives appearing during the oxidative metabolism of chlorpromazine with NADPH-dependent microsomal oxygenases, and by the 2) competition for reduced components of electron-carriers between the NADPH-dependent processes: chlorpromazine metabolism and lipids peroxidation.
摘要
发现氯丙嗪对大鼠肝微粒体部分中依赖NADPH的酶促脂质过氧化有抑制作用。这种抑制是由以下原因引起的：1）氯丙嗪与依赖NADPH的微粒体加氧酶进行氧化代谢时出现的羟基衍生物的抗氧化作用；2）在依赖NADPH的过程（氯丙嗪代谢和脂质过氧化）之间对电子载体还原成分的竞争。
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