de Nutte N, Demeester-Mirkine N, Six R, Corvilain J, de Backer M
Horm Metab Res. 1978 Jul;10(4):315-8. doi: 10.1055/s-0028-1097112.
Urinary cyclic AMP was studied in 22 female and in 6 male hyperthyroid normocalcemic patients and in 3 hyperthyroid hypercalcemic men. Cyclic AMP/creatinine ratios were elevated both in female (4.12 +/- 0.26 mumoles/gm creatinine) and male (3.92 +/- 0.41 mumoles/gm creatinine) hyperthyroid normocalcemic patients as compared with normal female and male controls (2.85 +/- 0.20 and 2.54 +/- 0.14 mumoles/gm creatinine, respectively). However, there was no difference in the 24-hour urinary cyclic AMP excretion of both hyperthyroid and normal subjects. The hyperthyroid hypercalcemic men excreted less (2.47 +/- 0.19) mumoles/24 hr) cyclic AMP/24 hr than the normal male controls. In the thirteen female patients, studied when euthyroid, the cyclic AMP/creatinine ratio was normalised.
对22名女性和6名男性甲状腺功能亢进但血钙正常的患者以及3名甲状腺功能亢进且血钙过高的男性进行了尿中环磷酸腺苷（cAMP）的研究。与正常女性和男性对照组（分别为2.85±0.20和2.54±0.14微摩尔/克肌酐）相比，女性（4.12±0.26微摩尔/克肌酐）和男性（3.92±0.41微摩尔/克肌酐）甲状腺功能亢进但血钙正常的患者的环磷酸腺苷/肌酐比值均升高。然而，甲状腺功能亢进患者和正常受试者的24小时尿中环磷酸腺苷排泄量并无差异。甲状腺功能亢进且血钙过高的男性每24小时排泄的环磷酸腺苷（2.47±0.19微摩尔/24小时）比正常男性对照组少。在13名处于甲状腺功能正常状态时接受研究的女性患者中，环磷酸腺苷/肌酐比值恢复正常。
