Abello R, Buitrago C, Prate C M, DeVizio W, Bakar S K
Escuela de Odontologia, Universidad Javeriana, Bogota, Colombia.
Am J Dent. 1990 Sep;3 Spec No:S57-61.
Twenty male and female adult subjects were entered into a 7-week, double-blind clinical study to determine the effect on plaque formation of a mouthrinse containing 0.03% [corrected] triclosan and 0.25% of a copolymer of methoxyethylene and maleic acid, as compared to 1) a water placebo mouthrinse, 2) a matching alcohol placebo mouthrinse, and 3) Plax antiplaque pre-brushing dental rinse. The subjects were stratified according to their initial plaque scores and assigned in a type of randomized block design (repeated Latin square), so that each subject received each of the four mouthrinses only once for 1 week during the study. The subjects did not use any other oral hygiene procedure (including use of a toothbrush and dentifrice) during the 1-week period of time when they rinsed with their assigned mouthrinse product. The results indicated that use of the triclosan/copolymer mouthrinse provided a 49.8% reduction in supragingival plaque formation compared to the water placebo mouthrinse. The difference was statistically significant at the 99% level of confidence (P less than .01). Similarly, the use of the triclosan/copolymer mouthrinse provided a 47.6% reduction in supragingival plaque formation compared to Plax antiplaque pre-brushing dental rinse. The difference was statistically significant at the 99% level of confidence (P less than .01). The results further indicated that use of the triclosan/copolymer provided a 31.2% reduction in supragingival plaque formation compared to the alcohol placebo mouthrinse. The difference was statistically significant at the 99% level of confidence (P less than .01).
20名成年男女受试者参与了一项为期7周的双盲临床研究，以确定含0.03%[校正后]三氯生和0.25%甲氧基乙烯与马来酸共聚物的漱口水对牙菌斑形成的影响，将其与1）水安慰剂漱口水、2）匹配的酒精安慰剂漱口水以及3）Plax防菌斑刷牙前口腔冲洗液进行比较。受试者根据其初始牙菌斑评分进行分层，并采用一种随机区组设计（重复拉丁方）进行分配，以便在研究期间，每位受试者仅在1周内使用一次这四种漱口水。在使用指定漱口水产品进行漱口的1周时间内，受试者未使用任何其他口腔卫生措施（包括使用牙刷和牙膏）。结果表明，与水安慰剂漱口水相比，使用三氯生/共聚物漱口水可使龈上牙菌斑形成减少49.8%。在99%的置信水平下，差异具有统计学意义（P小于0.01）。同样，与Plax防菌斑刷牙前口腔冲洗液相比，使用三氯生/共聚物漱口水可使龈上牙菌斑形成减少47.6%。在99%的置信水平下，差异具有统计学意义（P小于0.01）。结果还表明，与酒精安慰剂漱口水相比，使用三氯生/共聚物可使龈上牙菌斑形成减少31.2%。在99%的置信水平下，差异具有统计学意义（P小于0.01）。
