脱水对大鼠中枢胆碱能刺激所产生的动脉压升高及肾电解质排泄的影响。

Effect of dehydration on the increase of arterial pressure and renal electrolyte excretion produced by central cholinergic stimulation in rats.

作者信息

Barbosa S P, Saad W A, Camargo L A, Renzi A, de-Luca Júnior L A, Haibara A S, Saad W A, Menani J V

机构信息

Departamento de Ciências Fisiológicas, Faculdade de Odontologia, Universidade Estadual Paulista, Araraquara, Brasil.

出版信息

Braz J Med Biol Res. 1990;23(9):927-9.

PMID:2101336

Abstract

Natriuresis, kaliuresis, diuresis, arterial pressure and heart rate were studied in rats following dehydration and cholinergic stimulation of the medial septal area (MSA). The increase in renal Na+ and K+ excretion produced by the injection of carbachol (2 nmol) into the MSA in normal hydrated rats was abolished in 48-h water-deprived rats. Urinary volume was also reduced. Cholinergic stimulation of the MSA produced a smaller increase in arterial pressure in 48-h water-deprived rats compared to normal hydrated animals. No change was observed in heart rate. These results show that hydration state is essential for the central cholinergic control of electrolyte excretion and increase in arterial pressure.

摘要

在对大鼠进行脱水处理以及对内侧隔区（MSA）进行胆碱能刺激后，研究了其利钠作用、利钾作用、利尿作用、动脉血压和心率。在正常水合状态的大鼠中，向MSA注射卡巴胆碱（2 nmol）会使肾钠和钾排泄增加，但在48小时缺水的大鼠中，这种增加被消除。尿量也减少。与正常水合的动物相比，在48小时缺水的大鼠中，对MSA的胆碱能刺激使动脉血压升高幅度较小。心率未观察到变化。这些结果表明，水合状态对于中枢胆碱能对电解质排泄的控制以及动脉血压升高至关重要。