Tani K, Yasuoka S, Ogushi F, Noda Y, Asada K, Ozaki T, Ogura T
Third Department of Internal Medicine, School of Medicine, Tokushima University, Japan.
Jpn J Med. 1990 Nov-Dec;29(6):576-82. doi: 10.2169/internalmedicine1962.29.576.
Increased fibroblast growth-stimulating activity (FGA) was found in bronchoalveolar lavage fluid (BALF) from sarcoidosis patients. For evaluation of the significance of FGA in disease activity and the pathophysiology of sarcoidosis, the FGA levels were compared with data on cellular analysis of BALF, serum angiotensin-converting enzyme (S-ACE) activity and chest radiograms. The FGA level was significantly higher in sarcoidosis patients with parenchymal involvement (radiological stages II and III) than in those without parenchymal involvement (radiological stage I). The FGA was positively correlated with albumin and fibronectin concentrations in BALF. However, it was not significantly correlated with the ratio of CD-4 + to CD-8 + T-lymphocytes in BALF or the S-ACE level, which are known to be useful in evaluating the disease activity of sarcoidosis. These results indicate that the diagnostic value of FGA is different from that of the lymphocyte subpopulations in BALF and S-ACE, and is useful in estimating the extent of parenchymal involvement in sarcoidosis.
在结节病患者的支气管肺泡灌洗液（BALF）中发现成纤维细胞生长刺激活性（FGA）增加。为了评估FGA在疾病活动度和结节病病理生理学中的意义，将FGA水平与BALF细胞分析数据、血清血管紧张素转换酶（S-ACE）活性及胸部X线片进行比较。有实质受累的结节病患者（放射学分期II和III期）的FGA水平显著高于无实质受累的患者（放射学分期I期）。FGA与BALF中的白蛋白和纤连蛋白浓度呈正相关。然而，它与BALF中CD-4 +与CD-8 + T淋巴细胞的比例或S-ACE水平无显著相关性，而后者已知可用于评估结节病的疾病活动度。这些结果表明，FGA的诊断价值不同于BALF中淋巴细胞亚群和S-ACE的诊断价值，并且有助于评估结节病实质受累的程度。
