[The radiation sensitizing activity of metronidazole and iso-metronidazole (1-(2-hydroxyethyl)-2-methyl-4-nitroimidazole)].
作者信息
Proskurjakov S J, Smoryzanova O A, Rjabcenko N I, Dedenkov A N
机构信息
Labor für Molekularbiologie, AdmW, UdSSR, Obninsk.
出版信息
Radiobiol Radiother (Berl). 1990;31(6):531-6.
PMID:2101458
Abstract
The effect of irradiation, metronidazole and iso-metronidazole on survival and number of tumor cells was analysed in vitro in mice that were inoculated with La-hemocytoblastosis--or Ehrlich-ascites-tumor cells after processing. It was shown that metronidazole and iso-metronidazole nearly have the same radiosensitizing activity on these conditions. The effect was dependent on concentration of compounds and cell type. With intraperitoneal application the iso-metronidazole was eliminated from Lewis-lung-carcinoma more slowly than from blood.
摘要
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