Widel M, Watras J, Suwiński J, Salwińska E
Teleradiotherapy Department, Silesian Polytechnical University, Gilwice, Poland.
Radiobiol Radiother (Berl). 1990;31(6):537-43.
The radiosensitizing effectiveness of 1-(2-hydroxy-3-methoxy-propyl)-2-chloro-4-nitroimidazole (P40) dependent on various fractionated schedules was tested in the rat solid tumor, rhabdomyosarcoma R 1. P40 combined conventional fractionation of gamma rays exerted no radiosensitizing effect measured as local control and growth delay as well. In contrary, the significant sensitization has been noticed when nontoxic doses of the nitroimidazole were combined with higher (3.7 Gy) doses of radiation. Low toxicity of P40 is encouraging for further experimental studies.
在大鼠实体瘤横纹肌肉瘤R1中，测试了1-(2-羟基-3-甲氧基丙基)-2-氯-4-硝基咪唑（P40）在不同分次照射方案下的放射增敏效果。P40与γ射线的传统分次照射联合使用时，无论是以局部控制还是生长延迟来衡量，均未产生放射增敏作用。相反，当无毒剂量的硝基咪唑与较高剂量（3.7 Gy）的辐射联合使用时，观察到了显著的增敏作用。P40的低毒性为进一步的实验研究提供了鼓励。
