Chang A R
Department of Pathology, University of Otago Medical School, Dunedin, New Zealand.
Cytopathology. 1990;1(6):321-8. doi: 10.1111/j.1365-2303.1990.tb00369.x.
An overview of studies attempting to define the natural history of carcinoma in situ of the cervix suggests that 20-30% of lesions progress to invasive carcinoma within 5-10 years. This risk of invasion and the inability to predict when invasion might occur has been reinforced by a judicial enquiry in New Zealand so that protocols that include withholding treatment are no longer justifiable. Once a diagnosis of cervical carcinoma in situ is established appropriate treatment is mandatory.
试图明确宫颈原位癌自然病程的各项研究综述表明，20%至30%的病变会在5至10年内进展为浸润癌。新西兰的一项司法调查强化了这种浸润风险以及无法预测何时会发生浸润的情况，因此不再有理由采用包括延迟治疗在内的方案。一旦确诊为宫颈原位癌，就必须进行适当治疗。
