Mapstone N P, Zakhour H D
Department of Histopathology, Arrowe Park Hospital, Wirral, Merseyside.
Cytopathology. 1990;1(6):349-55. doi: 10.1111/j.1365-2303.1990.tb00372.x.
In an attempt to discover the morphometric variables with the most diagnostic power in the differentiation of benign from malignant breast disease, 20 unequivocally benign and 20 unequivocally malignant and histologically confirmed breast aspirates were examined on an image analyser. It was found that standard deviation of nuclear area was the most discriminant variable. Then 23 aspirates initially diagnosed as 'suspicious of malignancy' were measured by the same technique, and standard deviation of nuclear area correctly differentiated all but three cases.
为了发现对鉴别乳腺良性疾病和恶性疾病最具诊断价值的形态计量学变量，我们在图像分析仪上对20例明确为良性、20例明确为恶性且经组织学证实的乳腺抽吸物进行了检查。结果发现核面积标准差是最具鉴别力的变量。然后，采用相同技术对最初诊断为“可疑恶性”的23例抽吸物进行测量，核面积标准差正确鉴别出了除3例外的所有病例。
