Cruciani M, Navarra A, Di Perri G, Danzi M C, Concia E, Bassetti D
Institute of Infectious Diseases, University of Verona, Italy.
Drugs Exp Clin Res. 1990;16(11):565-8.
The in vitro activity of cefotaxime and desacetylcefotaxime against Staphylococcus aureus, Staph. epidermidis and Streptococcus pyogenes was investigated. Synergy studies were performed using time-kill curves and the chequerboard test. The time-kill curves were performed on five strains each of Staph. aureus, Staph. epidermidis and Strep. pyogenes; cefotaxime and desacetylcefotaxime were tested alone or in combination at MIC and sub-MIC values. The chequerboard test was performed in microtitre plates on ten strains each of Staph. aureus, Staph. epidermidis and Strep. pyogenes: the results were interpreted by the fractional inhibitory concentration index. In some cases both methods showed synergistic interaction against the staphylococci tested. Indifference was observed against Strep. pyogenes.
研究了头孢噻肟和去乙酰头孢噻肟对金黄色葡萄球菌、表皮葡萄球菌和化脓性链球菌的体外活性。使用时间杀菌曲线和棋盘格试验进行协同研究。对金黄色葡萄球菌、表皮葡萄球菌和化脓性链球菌的五个菌株分别进行了时间杀菌曲线实验；头孢噻肟和去乙酰头孢噻肟分别以MIC和亚MIC值单独或联合进行测试。在微量滴定板上对金黄色葡萄球菌、表皮葡萄球菌和化脓性链球菌的十个菌株分别进行了棋盘格试验：结果通过分数抑菌浓度指数进行解释。在某些情况下，两种方法均显示出对所测试葡萄球菌的协同相互作用。对化脓性链球菌观察到无作用。
