Heise W, Arasteh K, L'age M
II. Innere Abteilung (Gastroenterologie und Infektiologie), Auguste-Viktoria-Krankenhaus, Berlin.
Mycoses. 1990;33 Suppl 1:32-6.
Esophageal candidosis was found endoscopically in 135 of 496 AIDS patients with upper gastrointestinal symptoms. Vomiting, dysphagia and retrosternal pain were the leading symptoms. Endoscopy showed different stages of esophagitis with Candida patches as early changes up to severe esophagitis with hemorrhage. 36 patients were treated with fluconazole orally or intravenously administered (100 mg per day). In 33 of 36 patients clinical, endoscopic and microbiological results were good with complete cure of the lesions after 7, 14 or 21 days of treatment. In 3 patients with wasting syndrome and severe opportunistic infections a resistance to the drug was discussed because of lack of sufficient therapy results. Maintenance therapy seems to be necessary to prevent relapses.
在496例有上消化道症状的艾滋病患者中，经内镜检查发现135例有食管念珠菌病。呕吐、吞咽困难和胸骨后疼痛是主要症状。内镜检查显示食管炎处于不同阶段，早期表现为念珠菌斑，严重时可出现伴有出血的食管炎。36例患者接受了口服或静脉注射氟康唑治疗（每日100毫克）。36例患者中有33例在治疗7、14或21天后，临床、内镜和微生物学检查结果良好，病变完全治愈。3例患有消耗综合征和严重机会性感染的患者，由于治疗效果不佳，讨论了对该药物的耐药性问题。似乎有必要进行维持治疗以防止复发。
