Valensi F, Durand V, Bastenaire B, Flandrin G
Laboratoire central d'Hématologie, Hôpital Saint-Louis, Paris.
Nouv Rev Fr Hematol (1978). 1990;32(6):409-14.
Splenic B cell lymphoma with circulating villous lymphocytes (SLVL) is a lymphoproliferative disorder characterized by the presence in the peripheral blood of atypical B-lymphocytes with hairy appearance. Although the clinical features with massive splenomegaly, absence of peripheral lymphadenopathy and blood cytopenia may mimic hairy cell leukemia (HCL), precise analysis of the morphologic and immunologic features allow differential diagnosis between these two entities. Bone marrow and spleen histology resemble the pattern in chronic lymphocytic leukemia (CLL). We studied 8 patients with this entity illustrating the difficulty of diagnosis between SLVL and HCL.
伴有循环绒毛淋巴细胞的脾B细胞淋巴瘤（SLVL）是一种淋巴增殖性疾病，其特征是外周血中存在具有毛发样外观的非典型B淋巴细胞。尽管其临床特征如巨大脾肿大、无外周淋巴结病和血细胞减少可能类似于毛细胞白血病（HCL），但对形态学和免疫学特征的精确分析有助于鉴别这两种疾病。骨髓和脾脏组织学类似于慢性淋巴细胞白血病（CLL）的模式。我们研究了8例该疾病患者，说明了SLVL和HCL之间诊断的困难。
