[伴有绒毛状淋巴细胞的脾淋巴瘤：形态学、免疫学及分子学研究。三例报告]

[Splenic lymphoma with villous lymphocytes: morphologic, immunologic and molecular study. Report of three cases].

作者信息

Labouyrie E, Chartois-Leauté A G, Dubus P, Duchayne E, Brousset P, Ceccaldi J, Capbern M, Fialon P, Soubeyran P, Delsol G, de Mascarel A, Merlio J P

机构信息

Laboratoire d'Anatomie Pathologique, Hôpital Haut-Levêque, CHU Bordeaux.

出版信息

Ann Pathol. 1996 Sep;16(4):285-91.

PMID:9172620

Abstract

Splenic lymphoma with villous lymphocytes (SLVL) is a low grade lymphoproliferation characterized by a massive splenomegaly, an absence of lymphadenopathy and the presence in the peripheral blood of atypical B-lymphocytes with hairy-cell appearance. We have studied the morphological, immunological and molecular characteristics of 3 cases of SLVL. SLVL presented on blood smears characteristic irregularities of the plasma membrane consisting in thin and short villi unevenly distributed. The main phenotype was CD5-, CD11c+, and CD25-, but individual SLVL cases can not be identified by using immunohistochemical criteria alone. Clonal rearrangements of the immunoglobulin heavy chain gene were found in all 3 cases and in one case presented a bcl2-JH rearrangement. SLVL are clonal B-cell lymphoproliferations and can be associated with t(14; 18) translocation.

摘要

伴有绒毛状淋巴细胞的脾淋巴瘤（SLVL）是一种低度淋巴细胞增殖性疾病，其特征为脾肿大、无淋巴结病以及外周血中出现具有毛细胞外观的非典型B淋巴细胞。我们研究了3例SLVL的形态学、免疫学和分子特征。SLVL在血涂片上表现为质膜特征性不规则，表现为分布不均的薄而短的绒毛。主要表型为CD5-、CD11c+和CD25-，但仅用免疫组化标准无法鉴别个别SLVL病例。在所有3例中均发现免疫球蛋白重链基因的克隆重排，其中1例出现bcl2-JH重排。SLVL是克隆性B细胞淋巴细胞增殖，可能与t(14; 18)易位有关。