Synthesis and biological activity of novel carbocyclic nucleosides.
作者信息
Marquez V E, Bodenteich M, Copp R R, Lim B B
机构信息
Laboratory of Medicinal Chemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
出版信息
Nucleic Acids Symp Ser. 1990(22):35-6.
PMID:2101908
Abstract
The syntheses of several novel carbocyclic nucleosides which incorporate the cyclopentene moiety of neplanocin A will be presented. These include modified pyrimidine derivatives of the very potent antitumor agent cyclopentenyl cytosine and carbocyclic analogues of the ketohexose nucleosides psicofuranine and psicofuranosyl cytosine.
摘要
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