嗜热四膜虫核酶中P3区域螺旋形成的热力学和动力学
Thermodynamics and kinetics for the helix formation of the P3 region in Tetrahymena ribozyme.
作者信息
Sugimoto N, Monden N, Sasaki M, Yamakage S, Takaku H
机构信息
Department of Chemistry, Faculty of Science, Konan University, Kobe, Japan.
出版信息
Nucleic Acids Symp Ser. 1990(22):45-6.
PMID:2101912
Abstract
The thermodynamic and kinetic results for the helix formation of the oligonucleotides, GACCGUCA and UGUCGGUC, which correspond to the sequence of the P3 region in Tetrahymena ribozyme are reported. The kinetic result suggested that the melting mechanism of the duplex of the oligonucleotides consisted of at least two steps because of a UU mismatch.
摘要
报道了与四膜虫核酶P3区域序列相对应的寡核苷酸GACCGUCA和UGUCGGUC形成螺旋的热力学和动力学结果。动力学结果表明，由于存在UU错配，寡核苷酸双链体的解链机制至少由两步组成。
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