具有氨基磷酸酯键的寡核苷酸类似物的结构与性质
Structure and properties of oligonucleotide analogs having phosphoramidate linkages.
作者信息
Kitamura M, Ozaki H, Yamana K, Shimidzu T
机构信息
Division of Molecular Engineering, Graduate School of Engineering, Kyoto University, Japan.
出版信息
Nucleic Acids Symp Ser. 1990(22):65-6.
PMID:2101917
Abstract
The oligothymidylate analogs, having several stereo regular phosphoramidate linkages, were synthesized. Melting temperatures(Tm) of complexes of the analogs and poly(dA) were measured by spectroscopic method. The abilities of the analogs to form the complexes with poly(dA) depended on their P-chirality of their modified linkages: one of the chiral isomers formed stable complexes, but another isomer formed less stable complexes.
摘要
合成了具有多个立体规则磷酰胺酯键的寡聚胸苷酸类似物。通过光谱法测量了这些类似物与聚（dA）形成的复合物的熔解温度（Tm）。这些类似物与聚（dA）形成复合物的能力取决于其修饰键的P-手性：其中一种手性异构体形成稳定的复合物，而另一种异构体形成的复合物稳定性较差。
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