Coiro V, d'Amato L, Marchesi C, Capretti L, Volpi R, Roberti G, Cerri L, Chiodera P
Institute of Internal Medicine, University of Parma, Italy.
Psychoneuroendocrinology. 1990;15(5-6):463-70. doi: 10.1016/0306-4530(90)90069-l.
The present study was undertaken in order to establish whether alterations in the endogenous opioid control of luteinizing hormone (LH) and ACTH/cortisol secretion occur in bulimic women with normal body weight and normal menstrual cycles. For this purpose, the capability of the opioid antagonist naloxone (4 mg injected as an intravenous bolus at time 0, plus 10 mg infused over 2 hr) to increase the circulating levels of LH and cortisol was tested in nine bulimic women and in nine age- and weight-matched normal controls. All women were tested on the 22nd day of a normal menstrual cycle. Two days later, a control test with normal saline (NaCl 0.9%) instead of naloxone was performed. The basal levels of LH and cortisol were similar in the bulimic and normal subjects and were not modified by the administration of normal saline. In contrast, the administration of naloxone significantly increased plasma LH and cortisol levels in all subjects, with peak LH responses at 30 min and peak cortisol responses at 60 min. The naloxone-induced LH and cortisol increases were significantly higher in the bulimic women than in the normal controls. These data indicate the presence of an increased opioid inhibitory tone in the control of LH and ACTH/cortisol secretion in normal weight bulimic women with normal menstrual cycles.
本研究旨在确定体重正常且月经周期正常的贪食症女性，其促黄体生成素（LH）和促肾上腺皮质激素/皮质醇分泌的内源性阿片类物质控制是否存在改变。为此，在9名贪食症女性和9名年龄及体重匹配的正常对照者中，测试了阿片类拮抗剂纳洛酮（0时静脉推注4mg，随后2小时内输注10mg）增加LH和皮质醇循环水平的能力。所有女性均在正常月经周期的第22天接受测试。两天后，用生理盐水（0.9%氯化钠）代替纳洛酮进行对照测试。贪食症患者和正常受试者的LH和皮质醇基础水平相似，且生理盐水给药未对其产生影响。相反，纳洛酮给药显著提高了所有受试者的血浆LH和皮质醇水平，LH反应峰值出现在30分钟，皮质醇反应峰值出现在60分钟。纳洛酮诱导的LH和皮质醇升高在贪食症女性中显著高于正常对照者。这些数据表明，在体重正常且月经周期正常的贪食症女性中，LH和促肾上腺皮质激素/皮质醇分泌的控制存在阿片类抑制作用增强的情况。
