Tsai C J, Kuo Y C, Chen P C, Wu C S
Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan, Republic of China.
Br J Clin Pract. 1990 Dec;44(12):603-8.
High mortality rates associated with mesenteric ischaemia are a tremendous challenge. We reviewed 43 patients admitted to Chang Gung Memorial Hospital between 1981 and 1988. A total of 24 patients (55.8%) had thrombosis or embolus of the superior mesenteric artery, five patients (11.6%) had superior mesenteric vein thrombosis, and 14 patients (32.6%) had non-occlusive infarction. Patients with mechanical obstructions (volvulus, intussusception, tumour compression, aortic dissection) causing mesenteric ischaemia were excluded. The initial symptoms were not specific before signs of peritonitis presented. The tetrad of leucocytosis (88.4%), metabolic acidosis (88.6%), hyperamylasaemia (46.9%) and elevated phosphate (33.3%) was noted to be significant. There was a high association with previous cardiovascular diseases (78.2%). The plain abdominal X-ray, which was the most frequently used investigative tool, showed suggestive but non-specific findings. A total of 38 patients (88.4%) were operated upon. In six patients (14%) the exploratory laparotomy was open and closed because the bowel gangrene was too extensive. The total mortality rate was 55.8%. To improve prognosis, clinical awareness of the problem should be raised and the use of mesenteric angiography should be encouraged in an attempt to obtain an early diagnosis.
肠系膜缺血相关的高死亡率是一项巨大挑战。我们回顾了1981年至1988年间入住长庚纪念医院的43例患者。共有24例患者(55.8%)发生肠系膜上动脉血栓形成或栓塞,5例患者(11.6%)发生肠系膜上静脉血栓形成,14例患者(32.6%)发生非闭塞性梗死。因机械性梗阻(肠扭转、肠套叠、肿瘤压迫、主动脉夹层)导致肠系膜缺血的患者被排除。在出现腹膜炎体征之前,初始症状并不具有特异性。发现白细胞增多(88.4%)、代谢性酸中毒(88.6%)、高淀粉酶血症(46.9%)和磷酸盐升高(33.3%)这一组症状具有重要意义。与既往心血管疾病有高度相关性(78.2%)。腹部平片是最常用的检查工具,显示有提示性但非特异性的表现。共有38例患者(88.4%)接受了手术。6例患者(14%)的剖腹探查术因肠坏疽范围过大而开腹后又关闭。总死亡率为55.8%。为改善预后,应提高对该问题的临床认识,并鼓励使用肠系膜血管造影术以试图获得早期诊断。