Ohtani I, Okamura H, Kobari M, Yamanobe S, Hoshino T, Yamaguchi M, Yamada H
Department of Otolaryngology, Fukushima Medical College, Japan.
Fukushima J Med Sci. 1990 Jun;36(1):1-10.
This study was designed to examine the combined ototoxic effects of cisplatin, an antitumor platinum compound, administration and electron beam irradiation on the inner ear of guinea pigs, histopathologically. One group received saline solution 4 ml/kg/day and the other group received cisplatin of 2 mg/4 ml/kg/day for five consecutive days. The right temporal bones of all animals of both groups were exposed to the electron beam of 14 Gy/day 3 hours after the daily injection of saline or cisplatin. All animals were sacrificed for inner ear histopathological findings 21 days after the last injection. A combination of cisplatin administration and electron beam irradiation produced a severe potentiation of the outer hair cell damage with no inner hair cell damage. Therefore, in treatment of head and neck carcinomas, it is important to pay attention to inner ear damage caused by combination therapy of cisplatin and electron beam irradiation which involves the inner ear.
本研究旨在通过组织病理学方法，检测抗肿瘤铂类化合物顺铂给药及电子束照射对豚鼠内耳的联合耳毒性作用。一组每天接受4ml/kg的生理盐水，另一组连续五天每天接受2mg/4ml/kg的顺铂。两组所有动物在每日注射生理盐水或顺铂3小时后，其右侧颞骨均接受14Gy/天的电子束照射。在最后一次注射21天后，处死所有动物以进行内耳组织病理学检查。顺铂给药与电子束照射联合导致外毛细胞损伤严重增强，而内毛细胞未受损。因此，在头颈癌治疗中，关注顺铂与涉及内耳的电子束照射联合治疗引起的内耳损伤很重要。
