Vujić D, Popović J, Paunić Z, Radmilović A, Radlović O
Prof Dr. Vasilije Jovanović Institute of Renal Diseases and Metabolic Disturbances, Zvezdara Clinical and Hospital Centre, Belgrade.
Srp Arh Celok Lek. 1990 Sep-Oct;118(9-10):403-5.
A great interest in IgA nephropathy was demonstrated in the last few years. Unfortunately, a complete picture of this chronic disease should not yet been made. The article deals with 7 patients with IgA nephropathy treated in our Institute. The following characteristics were examined during a long period of time (1-17 years): clinical picture, course of the disease, clinical and morphologic correlations. The disease is characterised by micro-and macro-haematuria. In 6 patients a moderate proteinuria and slow progression of the disease were noted. Hypertension, massive proteinuria and azothemia in IgA nephropathy suggested a bad prognosis of the disease. This was confirmed in one patient who developed terminal renal insufficiency within 4 months. The pathological finding by optic microscope revealed a wide spectrum of changes. The role of immunofluorescent microscopy is crucial in the diagnosis of this disease.
过去几年,人们对IgA肾病表现出了极大的兴趣。不幸的是,这种慢性疾病的全貌尚未完全明了。本文论述了我院收治的7例IgA肾病患者。在很长一段时间(1至17年)内对以下特征进行了研究:临床表现、病程、临床与形态学的相关性。该疾病的特点是镜下血尿和肉眼血尿。6例患者出现中度蛋白尿,疾病进展缓慢。IgA肾病患者出现高血压、大量蛋白尿和氮质血症提示预后不良。这在1例患者中得到证实,该患者在4个月内发展为终末期肾功能不全。光学显微镜下的病理检查发现了广泛的变化。免疫荧光显微镜检查在该疾病的诊断中起着至关重要的作用。