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[疣状毛癣菌和马毛癣菌培养物引起的犊牛实验性毛癣菌病]

[Experimental trichophytosis in calves caused by cultures of Trichophyton verrucosum and Trichophyton equinum].

作者信息

Rybnikár A, Chumela J, Vrzal V

机构信息

Bioveta, Ivanovice na Hané.

出版信息

Vet Med (Praha). 1990 Oct;35(10):595-600.

PMID:2102571
Abstract

Tests were performed on 130 one-month-old calves. In 16 animals, treatment with a suspension of Trichophyton verrucosum culture at the dosage of 5 mil. conidia for an area of 10 x 10 of the clipped skin caused clinical trichophytic changes. The length of the incubation time was shorter in the calves scarified before inoculation of the infecting culture (10 to 13 days), as compared with the group of calves without scarification of the skin (11 to 19 days). Only 3 in 6 calves, infected by the same dose into non clipped skin, did contract trichophytosis, manifesting themselves as separate mycotic deposits, which appeared 26 to 35 days after inoculation. Trichophytic changes lasted longest in the group with scarification of the infected area. The ID50 in T. verrucosum and T. equinum cultures was about 1500 conidia per one calf in the case of the method of infecting into clipped scarified skin (area 100 sq cm). A 10 times lower dose (150 conidia per one calf) of the T. verrucosum suspension did not induce visible mycotic changes, but the T. equinum inoculation produced infection in one of 10 calves.

摘要

对130头1月龄犊牛进行了试验。在16头动物中,用疣状毛癣菌培养物悬液以每10×10平方厘米剪毛皮肤500万个分生孢子的剂量进行处理,导致了临床毛癣菌病变化。与未进行皮肤划痕的犊牛组(11至19天)相比,在接种感染性培养物前进行划痕的犊牛潜伏期较短(10至13天)。将相同剂量接种到未剪毛皮肤中的6头犊牛中,只有3头感染了毛癣菌病,表现为接种后26至35天出现的散在真菌沉积。在感染区域进行划痕的组中,毛癣菌病变化持续时间最长。对于感染剪毛划痕皮肤(面积100平方厘米)的方法,疣状毛癣菌和马毛癣菌培养物的半数感染剂量(ID50)约为每头犊牛1500个分生孢子。疣状毛癣菌悬液剂量降低10倍(每头犊牛150个分生孢子)未引起可见的真菌变化,但马毛癣菌接种在10头犊牛中的1头引起了感染。

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