Dabbagh M N, Fürll M, Schäfer M
Veterinärmedizinische Fakultät, Karl-Marx-Universität Leipzig.
Arch Exp Veterinarmed. 1990;44(6):819-29.
Eleven cows in late lactation were exposed to butyric acid for three weeks and were compared to five controls. Two intraruminal doses were daily applied, that is 1.0 g/kg B.W. of butyric acid to six animals and 1.0 g/kg B.W. of sodium butyrate to another five. Decline in milk yield was clinically recorded in response to butyric acid, while muscle tremor and diarrhoea resulted additionally from sodium butyrate. Behaviours of the clinico-chemical parameters of beta-OH-butyrate, glucose, free fatty acids, bilirubin, ASAT, gamma-GT, AP, and cholesterol were comparable to those in fattening bulls. Liver damage was not safely established. Some of the clinico-chemical alterations were more strongly pronounced after administration of sodium butyrate. One cow fell ill with ketosis under butyric acid load.
11头处于泌乳后期的奶牛被暴露于丁酸环境中三周，并与5头对照奶牛进行比较。每天进行两次瘤胃内给药，即给6头奶牛施用1.0克/千克体重的丁酸，给另外5头奶牛施用1.0克/千克体重的丁酸钠。临床上记录到丁酸导致牛奶产量下降，而丁酸钠还额外导致肌肉震颤和腹泻。β-羟基丁酸、葡萄糖、游离脂肪酸、胆红素、谷草转氨酶、γ-谷氨酰转肽酶、碱性磷酸酶和胆固醇的临床化学参数行为与育肥牛的相当。未确凿证实存在肝脏损伤。丁酸钠给药后，一些临床化学改变更为明显。1头奶牛在丁酸负荷下患酮病。
