Tautt J, Mazur N, Koziorowska J
Institute for Drug Research and Control, Warsaw.
Arch Immunol Ther Exp (Warsz). 1990;38(3-4):223-7.
This paper reports effects of retinoic acid (RA) on the expression of plasminogen activator (PA) activity and their relation to the effects of the vitamin on cellular proliferation. RA at the concentrations of 10 microM ml and 1 microM/ml did not affect PA activity in the cells of human melanoma cell line 10-135 but produced a transient decrease of PA activity as well in two other human melanoma cell lines as in RK 13 and IAR 6-7 cells. Unlike 10-135 cells which were resistant to retinoic acid all the remaining cell lines were susceptible to inhibition of the growth by the vitamin. Replacement of the medium with RA by standard medium produced a reversal of the inhibitory effects of the vitamin on PA activity and cell proliferation.
本文报道了视黄酸（RA）对纤溶酶原激活剂（PA）活性表达的影响及其与该维生素对细胞增殖作用的关系。浓度为10微摩尔/毫升和1微摩尔/毫升的RA对人黑色素瘤细胞系10 - 135的细胞中的PA活性没有影响，但在另外两个人黑色素瘤细胞系以及RK 13和IAR 6 - 7细胞中，也使PA活性产生了短暂下降。与对视黄酸有抗性的10 - 135细胞不同，其余所有细胞系都易受该维生素抑制生长的影响。用标准培养基替换含RA的培养基可使维生素对PA活性和细胞增殖的抑制作用逆转。
