Tamai H, Nagai K, Ishimoto J, Matsubayashi S, Matsuzuka F, Miyauchi A, Kuma K, Nagataki S
Department of Psychosomatic Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Clin Nucl Med. 1990 Jul;15(7):465-7. doi: 10.1097/00003072-199007000-00002.
Thyroid scintigrams of two women (aged 48 and 58) with Plummer's disease showed unusual radioiodine accumulation during treatment with methimazole (MMI). Before MMI therapy, the scintigrams revealed most of the radioiodine uptake only in the nodules of the patients and very little uptake in the non-nodular portions of the thyroid. After initiation of MMI therapy, scintigrams performed at three and eight months revealed that the hot nodules had become hypofunctional and that the surrounding tissues had normal radioiodine accumulation. The findings indicate that the nodules in Plummer's disease continue to concentrate MMI selectively compared with normal surrounding thyroid tissue during therapy.
两名患有普卢默病的女性（年龄分别为48岁和58岁）的甲状腺闪烁扫描图显示，在接受甲巯咪唑（MMI）治疗期间出现了异常的放射性碘积聚。在MMI治疗前，闪烁扫描图显示大部分放射性碘仅在患者的结节中摄取，而在甲状腺的非结节部分摄取很少。开始MMI治疗后，在三个月和八个月时进行的闪烁扫描图显示，热结节功能减退，周围组织放射性碘积聚正常。这些发现表明，在治疗期间，普卢默病的结节与周围正常甲状腺组织相比，继续选择性地浓缩MMI。
