CNRS, Institut de Chimie des Substances Naturelles (ICSN), UPR 2301, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
J Org Chem. 2010 Dec 3;75(23):8190-8. doi: 10.1021/jo1018377. Epub 2010 Oct 28.
The synthesis of the highly functionalized tetracyclic skeleton of landomycinone (2), the aglycon of landomycins, was performed using two pivotal steps relying on metal-catalyzed reactions. They are (1) a [2 + 2 + 2] cycloaddition of alkynes promoted by Wilkinson's catalyst to build rings B and C concomitantly and (2) a ring-closing metathesis followed by aromatization to build ring D.
采用两步关键反应，完成了依赖于金属催化的反应来合成陆地霉酮（2）的高度官能化四环骨架，该化合物是兰地霉素的苷元。这两步反应分别是：（1）威尔金森催化剂促进的炔烃[2+2+2]环加成反应，同时构建环 B 和环 C；（2）闭环复分解反应，随后进行芳构化反应构建环 D。
