Department of Dermatology, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden.
Allergy. 2011 Mar;66(3):404-11. doi: 10.1111/j.1398-9995.2010.02487.x. Epub 2010 Sep 29.
Cross-sectional studies suggest an association between eczema and mental health problems, possibly modified by sleeping problems, but prospective evidence is missing. We aimed to prospectively investigate the relationship between infant eczema (within first 2 years of age), infant sleeping problems (within first 2 years of age), and the risk of mental health problems at 10 years of age.
Between 1997 and 1999, a population-based birth cohort was recruited in Munich, Leipzig, Wesel, and Bad Honnef, Germany, and followed until 10 years of age. Physician-diagnosed eczema, parent-reported sleeping problems, and known environmental risk factors for atopy were regularly assessed until 10 years of age. Mental health was measured using the Strengths and Difficulties Questionnaire (parent version) at 10 years of age. We applied logistic regression modeling adjusting for environmental and lifestyle factors, allergic comorbidity, and family history of eczema.
From the original cohort of 3097 neonates, 1658 (54%) were followed until age 10, while 1578 (51%) were eligible for analysis. In the fully adjusted model, children with infant eczema were at increased risk of hyperactivity/inattention at 10 years of age [odds ratio (OR) 1.78; 95% confidence interval (95% CI) 1.02-3.09]. Infant eczema with concurrent sleeping problems predicted emotional problems [OR 2.63; 95% confidence interval (95% CI) 1.20-5.76] and conduct problems (OR 3.03; 95% CI 1.01-9.12) at 10 years of age.
Infant eczema with concurrent sleeping problems appears to be a risk factor for the development of mental health problems.
横断面研究表明湿疹与心理健康问题之间存在关联，可能受到睡眠问题的影响，但缺乏前瞻性证据。我们旨在前瞻性调查婴儿湿疹（2 岁以内）、婴儿睡眠问题（2 岁以内）与 10 岁时心理健康问题风险之间的关系。
1997 年至 1999 年，在德国慕尼黑、莱比锡、韦塞尔和巴特洪内夫招募了一项基于人群的出生队列，并随访至 10 岁。定期评估医生诊断的湿疹、父母报告的睡眠问题以及特应性的已知环境危险因素，直至 10 岁。10 岁时使用长处与困难问卷（父母版）测量心理健康。我们应用逻辑回归模型，调整环境和生活方式因素、过敏合并症和湿疹家族史。
在最初的 3097 例新生儿队列中，有 1658 例（54%）随访至 10 岁，而有 1578 例（51%）符合分析条件。在完全调整的模型中，患有婴儿湿疹的儿童在 10 岁时多动/注意力不集中的风险增加[比值比（OR）1.78；95%置信区间（95%CI）1.02-3.09]。伴有睡眠问题的婴儿湿疹预测 10 岁时情绪问题[OR 2.63；95%置信区间（95%CI）1.20-5.76]和行为问题[OR 3.03；95%置信区间（95%CI）1.01-9.12]。
伴有睡眠问题的婴儿湿疹似乎是心理健康问题发展的危险因素。
