[Transformation of human bronchial epithelial cells BEP2D induced by ²³⁸Pu α-particles].
作者信息
Lou T, Xiang X, Wu D
机构信息
Institute of Radiation Medicine, Academy of Military Medicine Science , Beijing 100850, P . R. China.
出版信息
Zhongguo Fei Ai Za Zhi. 2000 Dec 20;3(6):428-31. doi: 10.3779/j.issn.1009-3419.2000.06.08.
BACKGROUND
To establish a model for the study of transformation of human cell by radon and its progeny.
METHODS
BEP2D, a HPV18 immortalized human bronchial epithelial cell line, was irradiated with high-energy α-particles emitted by ²³⁸Pu.
RESULTS
A single 1. 5 Gy dose of α-particles induced transformation of the cells. A series of sequential steps arose among transformed cells, including altered growth kinetics, resistance to serum-induced terminal differentiation, and anchorage-independence growth.
CONCLUSIONS
This cell line may provide a model to study the cellular and molecular changes at various stages in radiation carcinogenesis.
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