Department of Medicine, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232, USA.
Immunol Allergy Clin North Am. 2010 Nov;30(4):523-39, vi-vii. doi: 10.1016/j.iac.2010.08.006. Epub 2010 Sep 22.
Respiratory syncytial virus (RSV), a single-stranded RNA virus of the Paramyxoviridae family, is a major cause of bronchiolitis in infants and is also conjectured to be an early-life influence on the development of asthma. Although the data supporting a role for RSV in bronchiolitis in children are robust and evidence to support its role in juvenile asthmatics exists, RSV's role in asthma pathogenesis in adults is not as clearly defined. The authors review the literature to further elucidate RSV's impact on adult asthmatics, including its importance as a cause of asthma exacerbations. They examine the morbidity associated with RSV infection and how the immune response may differ between adult asthmatics and nonasthmatics. They review the responses by specific cell types from adults with asthma that are stimulated by RSV. They also consider the role of early-life exposure to RSV and its contribution to asthma in adults. Lastly, they review the mechanisms by which RSV evades normal host immune responses and subverts these responses to its benefit.
呼吸道合胞病毒（RSV）是副黏病毒科的单链 RNA 病毒，是婴儿细支气管炎的主要病因，据推测也是生命早期对哮喘发展的影响因素。尽管支持 RSV 在儿童细支气管炎中起作用的数据是可靠的，并且有证据支持其在青少年哮喘患者中的作用，但 RSV 在成人哮喘发病机制中的作用尚不清楚。作者查阅文献以进一步阐明 RSV 对成年哮喘患者的影响，包括其作为哮喘加重原因的重要性。他们研究了与 RSV 感染相关的发病率，以及成人哮喘患者和非哮喘患者的免疫反应可能有何不同。他们回顾了 RSV 刺激哮喘患者特定细胞类型的反应。他们还考虑了生命早期接触 RSV 及其对成人哮喘的贡献。最后，他们回顾了 RSV 逃避正常宿主免疫反应并利用这些反应为自身利益的机制。
