Moore E, Merali Z, Beninger R J
Department of Psychology Queen's University, Kingston, Canada.
Pol J Pharmacol Pharm. 1990 Nov-Dec;42(6):521-5.
Neuropeptide Y (NPY) is a member of the pancreatic polypeptide family and consists of 36 amino acids, sharing sequence homologies with the putative gut hormone peptides YY and PP. NPY dose-dependently stimulates food intake when administered icv into the paraventricular hypothalamic nucleus of rats. Icv NPY has also been reported to decrease locomotor activity, rearing and grooming behaviour. Little behavioural research focusing on other unconditioned behaviours has been conducted. However, intrastriatal injections of NPY have been shown to increase dopamine (DA) turnover there. As unilateral manipulations of central DA result in turning away from the side of higher DA activity, it is of interest to evaluate the effects of intrastriatal NPY on this behaviour. Preliminary results indicate that NPY produces a significant contralateral turning bias when injected directly into the striatum. This raises the intriguing possibility that contralateral turning induced by intrastriatal NPY may be mediated by DA.
神经肽Y（NPY）是胰多肽家族的成员，由36个氨基酸组成，与假定的肠道激素肽YY和PP具有序列同源性。当向大鼠下丘脑室旁核脑室内注射NPY时，它会剂量依赖性地刺激食物摄入。据报道，脑室内注射NPY还会降低运动活动、竖毛和梳理行为。针对其他非条件行为的行为学研究很少。然而，已证明纹状体内注射NPY会增加该部位的多巴胺（DA）周转率。由于中枢多巴胺的单侧操作会导致动物转向多巴胺活性较高的一侧，因此评估纹状体内注射NPY对这种行为的影响很有意义。初步结果表明，当直接注射到纹状体中时，NPY会产生明显的对侧转向偏向。这就提出了一个有趣的可能性，即纹状体内注射NPY诱导的对侧转向可能是由多巴胺介导的。
