Center of Infection and Immunity Amsterdam and Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Trends Immunol. 2010 Dec;31(12):452-9. doi: 10.1016/j.it.2010.08.002. Epub 2010 Oct 26.
Langerhans cells (LCs) are at the frontline in defense against mucosal infections because they line the mucosal tissues and are ideally situated to intercept pathogens. Recent data suggest that LCs have an innate anti-HIV-1 function. LCs express the LC-specific C-type lectin Langerin that efficiently captures HIV-1, which prevents HIV-1 transmission. However, immune activation of LCs changes these protective cells into HIV-1-transmitting cells, which indicates that the antiviral function of LCs depends on several factors including co-infections. In this review, we discuss the dual role of LCs in innate defense against pathogens, with a focus on HIV-1 dissemination.
朗格汉斯细胞（LCs）处于防御黏膜感染的第一线，因为它们排列在黏膜组织中，非常适合拦截病原体。最近的数据表明，LCs 具有先天抗 HIV-1 的功能。LCs 表达 LC 特异性 C 型凝集素朗格汉斯，可有效捕获 HIV-1，从而阻止 HIV-1 的传播。然而，LCs 的免疫激活会将这些保护性细胞转变为 HIV-1 传播细胞，这表明 LCs 的抗病毒功能取决于包括合并感染在内的多种因素。在这篇综述中，我们讨论了 LCs 在先天防御病原体中的双重作用，重点是 HIV-1 的传播。
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