DC-SIGN阳性树突状细胞和朗格汉斯细胞在HIV-1传播中的不同作用。
Distinct roles for DC-SIGN+-dendritic cells and Langerhans cells in HIV-1 transmission.
作者信息
de Witte Lot, Nabatov Alexey, Geijtenbeek Teunis B H
机构信息
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands.
出版信息
Trends Mol Med. 2008 Jan;14(1):12-9. doi: 10.1016/j.molmed.2007.11.001. Epub 2007 Dec 4.
Dendritic cells (DCs) are thought to mediate HIV-1 transmission but it is becoming evident that different DC subsets at the sites of infection have distinct roles. In the genital tissues, two different DC subsets are present: the Langerhans cells (LCs) and the DC-SIGN(+)-DCs. Although DC-SIGN(+)-DCs mediate HIV-1 transmission, recent data demonstrate that LCs prevent HIV-1 transmission by clearing invading HIV-1 particles. However, this protective function of LCs is dependent on the function of the C-type lectin Langerin: blocking Langerin function by high virus concentrations enables HIV-1 transmission by LCs. Here, we will discuss the molecular mechanisms involved in HIV-1 transmission and viral clearance. A better understanding of these processes is crucial to understand and develop strategies to combat transmission.
树突状细胞（DCs）被认为介导HIV-1传播，但越来越明显的是，感染部位的不同DC亚群具有不同的作用。在生殖器组织中，存在两种不同的DC亚群：朗格汉斯细胞（LCs）和DC-SIGN(+) -DCs。虽然DC-SIGN(+) -DCs介导HIV-1传播，但最近的数据表明，LCs通过清除入侵的HIV-1颗粒来预防HIV-1传播。然而，LCs的这种保护功能依赖于C型凝集素Langerin的功能：高病毒浓度阻断Langerin功能会使LCs介导HIV-1传播。在这里，我们将讨论HIV-1传播和病毒清除所涉及的分子机制。更好地理解这些过程对于理解和制定对抗传播的策略至关重要。
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