Ikeme M M, Adelaja A O
Faculty of Veterinary Medicine, University of Nigeria, Nsukka.
Rev Elev Med Vet Pays Trop. 1990;43(3):331-6.
The influence of administering sheep red cells (SRC) as antigens, either after or before a trypanosome challenge, on parasitaemia profile and antibody response was assessed in albino Wistar rats. High levels of parasitaemia associated with significantly depressed antibody response and packed cell volume (PCV) values were observed when trypanosome challenge preceded antigen stimulation. In contrast, a clear delay in the onset and development of parasitaemia occurred when antigen priming preceded trypanosome challenge. At the beginning, PCV values and antibody response to the antigen were in the range of levels found in control rats. However, as infection progressed, parasitaemia rose and significant immunological hyporesponsiveness developed which at least reached levels found in rats that had received trypanosome challenge prior to antigen stimulation. These findings should be taken into consideration when evaluating serological tests used for assessing responses to specific vaccinations, or for the diagnosis of infections based on rising antibody titres in the host.
在白化Wistar大鼠中评估了在锥虫攻击之前或之后给予绵羊红细胞（SRC）作为抗原对寄生虫血症谱和抗体反应的影响。当锥虫攻击先于抗原刺激时，观察到高水平的寄生虫血症与明显降低的抗体反应和血细胞比容（PCV）值相关。相反，当抗原引发先于锥虫攻击时，寄生虫血症的发生和发展明显延迟。开始时，PCV值和对抗原的抗体反应处于对照大鼠中发现的水平范围内。然而，随着感染的进展，寄生虫血症上升，并且出现了明显的免疫低反应性，其至少达到了在抗原刺激之前接受锥虫攻击的大鼠中发现的水平。在评估用于评估对特定疫苗接种的反应或基于宿主中抗体滴度升高诊断感染的血清学检测时，应考虑这些发现。
