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Possible misinterpretation of the mode of action of therapeutic antibodies in vitro: homotypic adhesion and flow cytometry result in artefactual direct cell death.

作者信息

Golay Josée, Bologna Luca, André Pierre-Alain, Buchegger Franz, Mach Jean Pierre, Boumsell Laurence, Introna Martino

出版信息

Blood. 2010 Oct 28;116(17):3372-3; author reply 3373-4. doi: 10.1182/blood-2010-06-289736.

DOI:10.1182/blood-2010-06-289736
PMID:21030571
Abstract
摘要

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Possible misinterpretation of the mode of action of therapeutic antibodies in vitro: homotypic adhesion and flow cytometry result in artefactual direct cell death.治疗性抗体体外作用模式可能的错误解读：同型黏附和流式细胞术导致人为的直接细胞死亡。
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[First monoclonal antibody accepted for cancer therapy].[首个被批准用于癌症治疗的单克隆抗体]
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A Review of Obinutuzumab (GA101), a Novel Type II Anti-CD20 Monoclonal Antibody, for the Treatment of Patients with B-Cell Malignancies.
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