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争议:辅助剂在男性型脱发管理中是否有作用?

Controversy: is there a role for adjuvants in the management of male pattern hair loss?

作者信息

Rajput Rajendrasingh J

机构信息

R R Institute, 201-A, Gasper Enclave, Ambedkar Road, Pali Hill Market, Bandra (W), Mumbai 400050, India.

出版信息

J Cutan Aesthet Surg. 2010 May;3(2):82-6. doi: 10.4103/0974-2077.69016.

DOI:10.4103/0974-2077.69016
PMID:21031065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2956962/
Abstract

Patients with hair loss are seeking treatment at a younger age and during earlier stages. Not all need hair transplants. Because of the lack of assured management and the fear of side-effects, patients are turning to ineffective alternative remedies from self-claimed experts. In this report, we discuss the available treatment options and how best they can be used in combination to produce satisfactory results. The traditional approach consists of administration of drugs such as minoxidil and finasteride. We propose a hypothesis that nutritional supplements, 2% ketoconazole shampoo and low-level laser therapy along with finasteride 1 mg used once in 3 days with 2% minoxidil used everyday, given in a cyclical medicine program may be useful to manage hair loss and achieve new hair growth. The scientific rationale for such an approach is explained. The need for further studies to establish the efficacy of the regime is stressed upon.

摘要

脱发患者寻求治疗的年龄越来越小,且处于疾病早期阶段。并非所有患者都需要进行植发。由于缺乏可靠的治疗方法且担心副作用,患者开始求助于自称专家的无效替代疗法。在本报告中,我们讨论了现有的治疗选择以及如何最佳地联合使用这些方法以取得满意的效果。传统方法包括使用米诺地尔和非那雄胺等药物。我们提出一个假设,即营养补充剂、2%酮康唑洗发水、低水平激光疗法,以及每三天服用一次1毫克非那雄胺并每天使用2%米诺地尔,按照周期性药物方案给药,可能有助于治疗脱发并促进新头发生长。文中解释了这种方法的科学原理。强调了需要进一步研究以确定该方案的疗效。

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Indian Dermatol Online J. 2019 Mar-Apr;10(2):115-124. doi: 10.4103/idoj.IDOJ_123_18.
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Use of low-level laser therapy as monotherapy or concomitant therapy for male and female androgenetic alopecia.低强度激光疗法作为男性和女性雄激素性脱发的单一疗法或联合疗法的应用。
Int J Trichology. 2014 Apr;6(2):45-9. doi: 10.4103/0974-7753.138584.
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Female pattern alopecia: current perspectives.女性型脱发:当前观点
Int J Womens Health. 2013 Aug 29;5:541-56. doi: 10.2147/IJWH.S49337.
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本文引用的文献

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HairMax LaserComb laser phototherapy device in the treatment of male androgenetic alopecia: A randomized, double-blind, sham device-controlled, multicentre trial.HairMax激光梳激光光疗设备治疗男性雄激素性脱发:一项随机、双盲、假设备对照、多中心试验。
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Big head? Bald head! Skull expansion: alternative model for the primary mechanism of AGA.大头?光头!颅骨扩张:雄激素性脱发主要机制的替代模型。
Med Hypotheses. 2009 Jan;72(1):23-8. doi: 10.1016/j.mehy.2008.07.048. Epub 2008 Sep 11.
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Male pattern baldness: current treatments, future prospects.男性型秃发:当前治疗方法与未来前景
Drug Discov Today. 2008 Sep;13(17-18):791-7. doi: 10.1016/j.drudis.2008.05.010. Epub 2008 Jul 24.
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Premature senescence of balding dermal papilla cells in vitro is associated with p16(INK4a) expression.体外秃发毛囊真皮乳头细胞的过早衰老与p16(INK4a)表达相关。
J Invest Dermatol. 2008 May;128(5):1088-94. doi: 10.1038/sj.jid.5701147. Epub 2007 Nov 8.
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The effect of tripeptide-copper complex on human hair growth in vitro.三肽铜络合物对人毛发生长的体外影响。
Arch Pharm Res. 2007 Jul;30(7):834-9. doi: 10.1007/BF02978833.
6
Finasteride 5 mg and sexual side effects: how many of these are related to a nocebo phenomenon?非那雄胺5毫克与性副作用:其中有多少与反安慰剂现象有关?
J Sex Med. 2007 Nov;4(6):1708-12. doi: 10.1111/j.1743-6109.2007.00563.x. Epub 2007 Jul 26.
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