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Six hundred twenty kidney transplants have been performed at UCLA since 1984. Rather than 1 rigid immune suppression protocol for all patients, an individualized approach has been taken since the advent of OKT3 in 1987. Since then, the 1-year cadaver graft and patient survival rates have been 87% and 97%, respectively, for both primary and repeat transplants, including various categories of high-risk recipients. 2. Delayed graft function, HLA matching, and percent prior sensitization were major determinants of graft survival. Race, age, and diabetes were not significant determinants of graft outcome. 3. Small children had a 94% 1-year graft survival rate following cadaver transplantation. Sequential immune suppression, the use of large kidneys, and careful perioperative fluid management to prevent graft thrombosis may be responsible for the graft survival rate. 4. Long-term (1 year) results continue to show deterioration in graft survival. Many patients are hypertensive and hypercholesterolemic. Many children are noncompliant with medications.

自1984年以来，加州大学洛杉矶分校已进行了620例肾移植手术。自1987年OKT3问世以来，采取的是针对所有患者的个性化方法，而非单一严格的免疫抑制方案。从那时起，包括各类高危受者在内的初次和再次移植的1年尸体供肾移植存活率和患者存活率分别为87%和97%。
移植肾功能延迟恢复、HLA配型和既往致敏百分比是移植物存活的主要决定因素。种族、年龄和糖尿病不是移植物结局的显著决定因素。
小儿尸体肾移植后1年移植物存活率为94%。序贯免疫抑制、使用大体积供肾以及围手术期仔细的液体管理以预防移植物血栓形成可能是移植物存活率高的原因。
长期（1年）结果继续显示移植物存活率下降。许多患者患有高血压和高胆固醇血症。许多儿童不遵医嘱服药。

Six hundred twenty kidney transplants have been performed at UCLA since 1984. Rather than 1 rigid immune suppression protocol for all patients, an individualized approach has been taken since the advent of OKT3 in 1987. Since then, the 1-year cadaver graft and patient survival rates have been 87% and 97%, respectively, for both primary and repeat transplants, including various categories of high-risk recipients. 2. Delayed graft function, HLA matching, and percent prior sensitization were major determinants of graft survival. Race, age, and diabetes were not significant determinants of graft outcome. 3. Small children had a 94% 1-year graft survival rate following cadaver transplantation. Sequential immune suppression, the use of large kidneys, and careful perioperative fluid management to prevent graft thrombosis may be responsible for the graft survival rate. 4. Long-term (1 year) results continue to show deterioration in graft survival. Many patients are hypertensive and hypercholesterolemic. Many children are noncompliant with medications.

自1984年以来，加州大学洛杉矶分校已进行了620例肾移植手术。自1987年OKT3问世以来，采取的是针对所有患者的个性化方法，而非单一严格的免疫抑制方案。从那时起，包括各类高危受者在内的初次和再次移植的1年尸体供肾移植存活率和患者存活率分别为87%和97%。
移植肾功能延迟恢复、HLA配型和既往致敏百分比是移植物存活的主要决定因素。种族、年龄和糖尿病不是移植物结局的显著决定因素。
小儿尸体肾移植后1年移植物存活率为94%。序贯免疫抑制、使用大体积供肾以及围手术期仔细的液体管理以预防移植物血栓形成可能是移植物存活率高的原因。
长期（1年）结果继续显示移植物存活率下降。许多患者患有高血压和高胆固醇血症。许多儿童不遵医嘱服药。

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